Titanium alloy medical field and orthopedic field

With the development and development of titanium alloy, the increase of titanium material varieties and the decrease of price, the application of titanium in civil industry increases exponentially. CFDA divides medical devices into three grades according to their safety from high to low, which are supervised and managed by three-level governments respectively. Implants made of titanium and titanium alloy materials belong to the third class of medical devices and are high-value consumables. The sub-industries with a market segment ratio of more than 5% include in vitro diagnosis, heart, imaging diagnosis, orthopedics, ophthalmology, and plastic surgery. Among them, in vitro diagnosis, orthopedics and cardiac intervention are the fastest growing high-value consumables in China. The application of biomedical titanium and its alloys went through three landmark phases: Initial application in the early 1950s, commercial pure titanium was first used in the manufacture of bone plates, screws, intramedullary nails and hip joints in the UK and USA. Also uses Ti-6Al-7Nb alloy to manufacture non-expandable intermedullary nail systems (tibia, humerus and femur) and hollow screws for femoral neck fractures. The orthopaedic medical device industry accounts for 9% of the global medical device market share and is still growing rapidly. The orthopaedic medical device market is mainly divided into four areas: trauma, joint, spine and others. Among them, trauma is the only subdivision that has not been occupied by foreign companies. The main reason is that the products in this field are of low technical content, easy to copy, and less difficult to operate, which can be carried out by many second and tertiary hospitals and cannot be fully covered by foreign companies. Trauma products can be divided into internal fixation and external fixation devices, and internal fixation trauma products include intramedullary nails, bone plates and screws, etc. In 2012, trauma accounted for 34%, joint 28%, spine 20%, and others 18% in the domestic orthopaedic market. Large joint is a high-end medical device with high technical barrier. At present, mainstream hospitals mainly import orthopedic materials, and there is still a gap between domestic and imported products in technology, design, research and development, materials, surface treatment process and other aspects. Artificial joints are mainly divided into artificial knee, hip, elbow, shoulder, finger and toe joints, among which the most major joint replacements include hip and knee joints, accounting for more than 95% of the global joint replacement market. Spinal implant devices include thoracolumbar nail plate system, cervical nail plate system and fusion device system, among which interbody fusion device system is mainly used for the treatment of disc replacement and is the most important segment, accounting for about half of the entire spinal implant market.