Application of titanium materials in pharmaceutical industry

The pharmaceutical industry is an important industry related to people's physical and mental health, including pharmaceutical, medical, mechanical and sanitary materials and other fields, occupies an important position in the national economy. Titanium is widely used in the pharmaceutical industry because it is non-toxic and has good compatibility with the human body. In pharmaceutical production, the production of drugs can not be separated from acid and alkali Salt, pharmaceutical equipment is easy to be corroded and damaged using steel equipment can not only solve the problem of serious corrosion of equipment, but also cause a lot of human, material and financial losses, affecting the normal production using titanium equipment is a good solution to this problem In the production of several main commonly used drugs, the equipment made of titanium material has good corrosion resistance and has obtained considerable economic benefits.

1 Production of Vitamin B1 in China multi-purpose hydrogen chloride conversion method to produce vitamin B1, finished products using cyclone drying two cyclone separation medium for thiamine hydrochloride, PH value of 2.5, temperature 110, strong corrosion of the original drying device for stainless steel material, use for more than a year on the inner wall of corrosion perforation, and serious pollution of drugs After using titanium spiral feeder cyclone separator vortex body hopper and discharge pipe and tail gas tank titanium lining, the production qualification rate of vitamin B1 is increased from 95% to 100%, and the equipment has not seen corrosion for more than 7 years, the cost of titanium can be recovered in 3 months.

2 Vitamin C in vitamin C production sorbitol as raw material, with black vinegar bacteria fermented into sorbose, reoccupy false single spore bacilli obtained low concentration fermentation cologne acid, concentrated by hydrogen chloride into finished products Titanium in high temperature cologne acid corrosion In the product production process, adopts the titanium shell and tube heat exchanger titanium DHC a settlement of 500 butterfly type automatic slag discharge centrifuge TC4 casting impeller has been used for many years without corrosion

. 3 The main raw material for chemical synthesis of chloramphenicol (an antibiotic) is methyl dichloroacetate, which contains about 2% trichloroethylene chloride. If steel equipment is used in the distillate process, it is prone to serious corrosion, and has been intact since titanium equipment is used.

4 Drug production Local anesthesia using procaine hydrochloride, and its production of nitrotoluene as raw material, the oxidation of preparing acetic acid washing p-nitrobenzoic acid mother liquor recycling the entire process of production, there is a strong corrosive, so the production equipment adopts the titanium steel clad plate cylinder Titanium bubble tube Glacial acetic acid circulation condenser and gas-liquid separator, so as to solve the corrosion problem.

5 Deworming drugs, and other pharmaceutical production drive hatched from net (tetramisole) is efficient intestinal nematodes deworming drugs, used in the product in the production of the original stainless steel equipment, pollution caused by corrosion products, using titanium as a feed pipe pump inlet pipe after successful to solve the corrosion problem Nitrate chlorophenol are special effects in the treatment of cattle and sheep fasciola hepatica veterinary drugs, production of nitric acid glacial acetic acid with sulfuric acid and chlorine solution Using titanium pin tank agitator, up to now operating normally In addition, the active carbon decoloring widely used in pharmaceutical production, change the stainless steel strainer to titanium after suction filter, using nine years is still intact Abroad in bromide in the production of amino acids, brominated separation salting-out extraction steam out of the process of titanium reactor has been adopted with quinoline derivatives for making malaria medicine in our country It is also necessary to use titanium equipment for anti-schistosomiasis drugs in contact with chloride ions, such as contraceptives, rheumatic drugs, etc., and other equipment, such as penicillin esterification kettle, saccharification tank, chloramphenicol film evaporator, Anagen reactor, Mituel filter, dimethyl sulfate cooler, liquid medicine filter, etc., are feasible and necessary to use titanium materials for manufacturing.